Way above my molecular pay grade, but from what I do understand the T-cell area of LN is an unusually acidic environment, which could explain how so many immune reactions can occur without the node becoming overwhelmed by inflammatory responses. "Our mechanism explains the apparent paradox of how the LN is able to host processes that underpin T-cells activation, while at the same time suppressing T-cells from invoking their effector functions while in residence." Maybe I need to update the #TalkingLymph post https://www.movinglymph.com.au/post/lymph-flow-valves-and-lymph-loading